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Delta-8临界胶束浓度对于药物在ayx爱游戏体育体内的增溶性的重要性研究——结论、致谢!

来源:上海谓载 浏览 1 次 发布时间:2021-12-21

结论


据我们所知,这是第一个全面的研究,清楚地显示了类药物化合物的内在表面性质对ayx爱游戏体育相关介质中溶解度增强的影响,而不是在水介质中。这项研究表明,临界胶束浓度(描述化合物在胶束中自缔合的内在能力)比公认的亲脂性更好地预测FaSSIF中的溶解度增强。我们的研究表明,考虑到化合物在胶束中结合的趋势,药物优化策略将潜在地受益,作为增加肠道吸收的一种方式。


作者信息


通讯作者


*电话:+41616881941。传真:+41616882908。电子邮件:鲁本。阿尔瓦雷斯_ sanchez roche.com.


笔记


作者声明没有相互竞争的经济利益。


致谢


作者要感谢比约恩·瓦格纳、维吉尼·米卡列夫、伊莎贝尔·帕里拉和萨宾·皮塔提供的技术援助,以及弗兰兹·舒勒、萨拉·贝利和乔恩·凯尔·博德纳尔对手稿的修订和宝贵意见。


缩写


FaSSIF,禁食状态模拟肠液;FeSSIF,喂食状态模拟肠液;临界胶束浓度;ayx爱游戏体育制药分类系统;SE,溶解度增强;logd,辛醇/水分配系数;电离常数


参考资料


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